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Naphazoline hydrochloride

Item number	681152
CAS	550-99-2
Formula	C14H15ClN2
Molecular weight	246,74 g/mol
Quantity	1x250mg
Storage conditions	20 °C
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Safety Data Sheet	according to Regulation (EC) No 1907/2006 (REACH) Classifications according to Regulation (EC) No 1272/2008. Printdate April 20, 2024
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:	Naphazoline hydrochloride
Catalog No.:	681152
Relevant identified uses of the substance or mixture	Identified: Laboratory chemical uses: R&D
Uses advised against:	HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. +49 34291 3372-36 Fax. +49 34291 3372-39 contact@hpc-standards.com
Emergency telephone number	HPC Standards Tel. +49 34291 3372-36 This number is only available during office hours.
HAZARDS IDENTIFICATION	· 2.1 Classification of the substance or mixture · Classification according to Regulation (EC) No 1272/2008 GHS06 skull and crossbones Acute Tox. 2 H300 Fatal if swallowed
Label elements
Pictogram	GHS06 skull skull
	· 2.2 Label elements · Labelling according to Regulation (EC) No 1272/2008 The substance is classified and labelled according to the CLP regulation. · Hazard pictograms GHS06 · Signal word Danger · Hazard statements H300 Fatal if swallowed. · Precautionary statements P264 Wash thoroughly after handling P270 Do not eat, drink or smoke when using this product. P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. P321 Specific treatment (see on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local/regional/national/international regulations. · 2.3 Other hazards · Results of PBT and vPvB assessment · PBT: Not applicable. · vPvB: Not applicable.
COMPOSITION/INFORMATION ON INGREDIENTS	· 3.1 Chemical characterisation: Substances · CAS No. Description 550-99-2 Naphazoline Hydrochloride · Identification number(s) None · EC number: 208-989-2 · RTECS: NJ4375000 · Additional information: For the wording of the listed hazard phrases refer to section 16.
Formula	C14H15ClN2
Molecular Weight (g/mol)	246.74
CAS-No.	550-99-2
FIRST AID MEASURES	· 4.1 Description of first aid measures · General information: Immediately remove any clothing soiled by the product. In case of irregular breathing or respiratory arrest provide artificial respiration. · After inhalation: Supply fresh air; consult doctor in case of complaints. · After skin contact: Immediately wash with water and soap and rinse thoroughly. · After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor. · After swallowing: Rinse mouth. Do not induce vomiting. Call for a doctor immediately. · 4.2 Most important symptoms and effects, both acute and delayed No further relevant information available. · 4.3 Indication of any immediate medical attention and special treatment needed No further relevant information available.
FIRE-FIGHTING MEASURES	· 5.1 Extinguishing media · Suitable extinguishing agents: Use fire extinguishing methods suitable for surrounding conditions. · 5.2 Special hazards arising from the substance or mixture Formation of toxic gases is possible during heating or in case of fire. 5.3 Advice for firefighters · Protective equipment: Wear self-contained respiratory protective device
ACCIDENTAL RELEASE MEASURES	· 6.1 Personal precautions, protective equipment and emergency procedures Wear protective clothing. · 6.2 Environmental precautions: Do not allow to enter sewers/ surface or ground water. · 6.3 Methods and material for containment and cleaning up: Dispose of contaminated material as waste according to item 13. · 6.4 Reference to other sections See Section 7 for information on safe handling. See Section 8 for information on personal protection equipment. See Section 13 for disposal information.
HANDLING AND STORAGE	· 7.1 Precautions for safe handling Remove dust thoroughly. Store in cool, dry place in tightly closed receptacles. · Information about fire - and explosion protection: No special measures required. · 7.2 Conditions for safe storage, including any incompatibilities · Storage: · Requirements to be met by storerooms and receptacles: Please refer to the manufacturers certificate for specific storage and transport temperature conditions. Store only in the original receptacle unless other advice is given on the CoA. Keep container in a well-ventilated place. Keep away from sources of ignition and heat. · Information about storage in one common storage facility: Store away from foodstuffs. · Further information about storage conditions: None. · 7.3 Specific end use(s) No further relevant information available.
EXPOSURE CONTROLS/PERSONAL PROTECTION	· Additional information about design of technical facilities: No further data; see item 7. · 8.1 Control parameters · Ingredients with limit values that require monitoring at the workplace: Not required. · Additional information: Lists used were valid at the time of SDS preparation. · 8.2 Exposure controls · Personal protective equipment: · General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing Wash hands before breaks and at the end of work. · Respiratory protection: Not required. Use suitable respiratory protective device in case of insufficient ventilation. · Protection of hands: The glove material has to be impermeable and resistant to the product/ the substance/ the preparation. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374 Protective gloves · Material of gloves Nitrile rubber, NBR · Penetration time of glove material The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed. · Eye protection: Safety glasses
PHYSICAL AND CHEMICAL PROPERTIES	· 9.1 Information on basic physical and chemical properties · General Information · Appearance: Form: Crystalline powder Colour: White · Odour: Odourless · Odour threshold: Not determined. · pH-value: Not applicable. · Change in condition Melting point/freezing point: 257-261 °C Initial boiling point and boiling range: Not determined. · Flash point: Not applicable. · Flammability (solid, gas): Not determined. · Ignition temperature: Not determined · Decomposition temperature: Not determined. · Auto-ignition temperature: Not determined. · Explosive properties: Not determined. · Explosion limits: Lower: Not determined. Upper: Not determined. · Vapour pressure: Not applicable. · Density: Not determined. · Relative density Not determined. · Vapour density Not applicable. · Evaporation rate Not applicable. · Solubility in / Miscibility with Ethanol · water: Soluble. · Partition coefficient: n-octanol/water: Not determined. · Viscosity: Dynamic: Not applicable. Kinematic: Not applicable. · 9.2 Other information No further relevant information available.
STABILITY AND REACTIVITY	· 10.1 Reactivity Stable under normal conditions. No further relevant information available. · 10.2 Chemical stability Stable under normal conditions. · Thermal decomposition / conditions to be avoided: Formation of toxic gases is possible during heating or in case of fire. · 10.3 Possibility of hazardous reactions No dangerous reactions known. · 10.4 Conditions to avoid Heat. · 10.5 Incompatible materials: Strong oxidizing agents. · 10.6 Hazardous decomposition products: Formation of toxic gases is possible during heating or in case of fire.
TOXICOLOGICAL INFORMATION	· 11.1 Information on toxicological effects · Acute toxicity Fatal if swallowed. · LD/LC50 values relevant for classification: Oral LD50 385 mg/kg (rat) 50 mg/kg (rabbit) LD 50 (Intraperitoneal) 50 mg/kg (rat) LD 50 (Intravenous) 6 mg/kg (rat) · Primary irritant effect: · Skin corrosion/irritation Based on available data, the classification criteria are not met. · Serious eye damage/irritation Based on available data, the classification criteria are not met. · Respiratory or skin sensitisation Based on available data, the classification criteria are not met. · CMR effects (carcinogenity, mutagenicity and toxicity for reproduction) · Germ cell mutagenicity Based on available data, the classification criteria are not met. · Carcinogenicity Based on available data, the classification criteria are not met. · Reproductive toxicity Based on available data, the classification criteria are not met. · STOT-single exposure Based on available data, the classification criteria are not met. · STOT-repeated exposure Based on available data, the classification criteria are not met. · Aspiration hazard Based on available data, the classification criteria are not met.
ECOLOGICAL INFORMATION	· 12.1 Toxicity · Aquatic toxicity: No further relevant information available. · 12.2 Persistence and degradability No further relevant information available. · 12.3 Bioaccumulative potential No further relevant information available. · 12.4 Mobility in soil No further relevant information available. · Additional ecological information: · General notes: Water hazard class 1 (German Regulation) (Self-assessment): slightly hazardous for water Do not allow undiluted product to reach ground water, water course or sewage system. · 12.5 Results of PBT and vPvB assessment · PBT: Not applicable. · vPvB: Not applicable. · 12.6 Other adverse effects No further relevant information available.
DISPOSAL CONSIDERATIONS	· 13.1 Waste treatment methods · Recommendation Must not be disposed of together with household garbage. Do not allow product to reach sewage system. · European waste catalogue Waste disposal key numbers from EWC have to be assigned depending on origin and processing. · Uncleaned packaging: · Recommendation: Dispose of in accordance with national regulations. · Recommended cleansing agents: Water, if necessary together with cleansing agents.
TRANSPORT INFORMATION	· 14.1 UN-Number · ADR, IMDG, IATA UN2811 · ADR 2811 TOXIC SOLID, ORGANIC, N.O.S. (Naphazoline Hydrochloride) · IMDG, IATA TOXIC SOLID, ORGANIC, N.O.S. (Naphazol ine Hydrochloride · 14.3 Transport hazard class(es) · ADR, IMDG, IATA · Class 6.1 Toxic substances. · Label 6.1 · 14.4 Packing group · ADR, IMDG, IATA II · 14.5 Environmental hazards: Not applicable. · 14.6 Special precautions for user Warning: Toxic substances. · Danger code (Kemler): 60 · EMS Number: F-A,S-A · Stowage Category B · 14.7 Transport in bulk according to Annex II of Marpol and the IBC Code Not applicable. · Transport/Additional information: · ADR · Limited quantities (LQ) 500 g · Excepted quantities (EQ) Code: E4 Maximum net quantity per inner packaging: 1 g Maximum net quantity per outer packaging: 500 g · Transport category 2 · Tunnel restriction code D/E · UN "Model Regulation": UN 2 8 1 1 TOXIC SOLID, ORGANIC, N.O. S . (NAPHAZOLINE HYDROCHLORIDE), 6.1, II
REGULATORY INFORMATION	· 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture · Directive 2012/18/EU · Named dangerous substances - ANNEX I Substance is not listed. · Seveso category H2 ACUTE TOXIC · Qualifying quantity (tonnes) for the application of lower-tier requirements 50 t · Qualifying quantity (tonnes) for the application of upper-tier requirements 200 t · 15.2 Chemical safety assessment: A Chemical Safety Assessment has not been carried out.
OTHER INFORMATION	The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. For lab use only!